Effect of cannabinoids on progesterone production by ovarian granulosa cells of pig and rat.

  title={Effect of cannabinoids on progesterone production by ovarian granulosa cells of pig and rat.},
  author={Young Sook Moon and Antoni J Duleba and Alexander Jakubovic},
  journal={Life sciences},
  volume={31 4},

Differential actions of FSH and androgens on progesterone catabolism by rat granulosa cells.

Androgenic alteration in pathways of C19-steroid metabolism by cultured rat granulosa cells.

Thein vivo effects of tetrahydrocannabinol on the activity of lactate and succinate dehydrogenases in rat preovulatory follicles

A dosage and regimen sufficient to cause significant decreases in the activities of steroidogenic enzymes had little effect on succinate and lactate dehydrogenases in rat preovulatory follicles.

Cannabinoids, Reproduction, and Sexual Behavior

The endocannabinoid system may possess the very realistic possibility of being a relevant system for the development of drugs that may help to treat erectile dysfunction, sexual arousal and desire disorders, and fertility in both men and women.

Effects of tetrahydrocannabinol on rat preovulatory follicles: a quantitative cytochemical analysis

Only the enzymes specifically associated with follicular steroidogenesis were affected by administration of the drug, tetrahydrocannabinol.

Temporal and Spatial Distribution of the Cannabinoid Receptors (CB1, CB2) and Fatty Acid Amide Hydroxylase in the Rat Ovary

Observations provide potential explanation for the effects of THC on steroidogenesis in the rat ovary observed by earlier investigators and a role for FAAH in the regulation of ovarian anandamide.



Inhibitory Effects of ▵9-Tetrahydrocannabinol on Glycolytic Substrates in the Rat Testis

Experiments conducted with rat testicular tissue indicated that Δ9-tetrahydrocannabinol (THC) produced a dose-dependent inhibition of glucose metabolism. Incubation of testicular tissue wit

Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice.

Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses, suggesting this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo.

Evidence that the effects of methadone and marihuana on male reproductive organs are mediated at different sites in rats.

It is concluded that methadone affects the male accessory sex organs indirectly by influencing the hypothalamic hypophyseal axis whereas �9-THC and CBN effects appear to be both direct at the tissue level and indirect at the hypothalamus-hypophyteal site.

Water-Soluble Derivatives of Δ1 Tetrahydrocannabinol

This work has shown that Δ1-Tetrahydrocannabinol, which is resinous and insoluble in water and therefore difficult to study pharmacologically, can be converted to a watersoluble derivative without loss of its biological activity.

Depression of plasma testosterone levels after chronic intensive marihuana use.

The data suggest that chronic intensive use of marihuana may produce alterations in male reproductive physiology through central (hypothalamic or pituitary) action.

Neuroendocrine Regulation and Altered Behaviour

This chapter discusses the role of Neuroendocrine Function in Anorexia Nervosa, and the importance of Plasma and Urine Amine Metabolites as Diagnostic and Pharmacodynamic Indicators in Psychiatric Disorders.