Effect of calmodulin inhibitors on viability and mitochondrial potential of Plasmodium falciparum in culture.

@article{Geary1986EffectOC,
  title={Effect of calmodulin inhibitors on viability and mitochondrial potential of Plasmodium falciparum in culture.},
  author={Timothy G. Geary and A A Divo and James E. Jensen},
  journal={Antimicrobial agents and chemotherapy},
  year={1986},
  volume={30 5},
  pages={785-8}
}
Calmodulin inhibitors are toxic for a variety of protozoa. Chlorpromazine, calmidazolium, and trifluoperazine inhibited the incorporation of [3H]hypoxanthine and [3H]phenylalanine into Plasmodium falciparum organisms in cultures with 50% inhibitory concentrations varying from 5.1 microM (with calmidazolium) to 48 microM (with chlorpromazine), the former being more sensitive than the latter. However, these concentrations also immediately dissipated rhodamine 123 from the parasite mitochondrion… CONTINUE READING

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