Effect of calcium ion concentrations on osteogenic differentiation and hematopoietic stem cell niche-related protein expression in osteoblasts.

@article{Nakamura2010EffectOC,
  title={Effect of calcium ion concentrations on osteogenic differentiation and hematopoietic stem cell niche-related protein expression in osteoblasts.},
  author={Shinya Nakamura and Takuya Matsumoto and Jun-ichi Sasaki and Hiroshi Egusa and Kuen Yong Lee and Takayoshi Nakano and Taiji Sohmura and Atsushi Nakahira},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 8},
  pages={
          2467-73
        }
}
Apatite biomaterials have potential not only as cell vehicles for engineering bone tissue but also as regulators of calcium (Ca) concentration in situ for controlling osteoblast functions, for example, osteogenic differentiation and fate management of hematopoietic stem cells (HSCs). To design apatite materials having optimal chemical properties for the latter purpose, more detailed investigations into what effect Ca concentrations have on osteoblast functions is crucial. In this study… CONTINUE READING

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