Effect of calcium channel blockers on theophylline disposition

@article{Sirmans1988EffectOC,
  title={Effect of calcium channel blockers on theophylline disposition},
  author={S. Sirmans and J. Pieper and R. Lalonde and D. Smith and T. Self},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1988},
  volume={44}
}
Twelve healthy subjects received a single oral dose of theophylline, 5 mg/kg alone, and after 7 days of oral verapamil, 120 mg every 8 hours, diltiazem, 90 mg every 8 hours, and nifedipine, 20 mg every 8 hours, in randomized crossover fashion. Mean theophylline oral clearance decreased 18% and 12% after verapamil and diltiazem, respectively (p < 0.05). No significant change in theophylline oral clearance was observed after nifedipine. Increases in mean theophylline half‐life were observed after… Expand
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