Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein.

@article{Cole1989EffectOC,
  title={Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein.},
  author={Susan P. C. Cole and Hilary Downes and Marilyn L. Slovak},
  journal={British Journal of Cancer},
  year={1989},
  volume={59},
  pages={42 - 46}
}
We have examined the ability of eight compounds to enhance adriamycin (ADM) sensitivity of two human tumour cell lines (a small cell lung cancer cell line, NCI-H69, and a fibrosarcoma cell line, HT1080) and their multidrug-resistant variants. The resistant cell lines (H69AR and HT1080/DR4) do not overexpress P-glycoprotein. Verapamil, nicardipine, perhexiline maleate, chloroquine, tamoxifen, clomiphene, prenylamine and trifluoperazine were tested alone and in combination with ADM for their… CONTINUE READING
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Multidrug resistance in multiple myeloma : Detection of P - glycoprotein in clinical specimens and reversal of resistance with verapamil

  • W. S. DALTON, B. G. M. DURIE, S. E. SALMON, T. M. GROGAN, R. J. SCHEPER, P. S. MELTZER
  • Blood
  • 1987
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