Effect of caffeine on parameters of osteoblast growth and differentiation of a mineralized extracellular matrix in vitro.

@article{Tassinari1991EffectOC,
  title={Effect of caffeine on parameters of osteoblast growth and differentiation of a mineralized extracellular matrix in vitro.},
  author={Mario Tassinari and Louis Charles Gerstenfeld and Gary S Stein and Jane B Lian},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1991},
  volume={6 10},
  pages={1029-36}
}
The effects of caffeine exposure on bone formation were examined using a chick osteoblast culture system. Secondary cultures of normal diploid osteoblasts were exposed to chronic doses of 0, 0.1, 0.2, or 0.4 mM caffeine beginning on day 0 through day 28. Neither the rate of cell proliferation nor cell number, as measured by total DNA, was decreased for any of the doses examined. In contrast, osteocalcin levels, alkaline phosphatase activity, and total calcium levels showed a dose-related… CONTINUE READING
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