Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats.

@article{Yang2008EffectOC,
  title={Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats.},
  author={Rong Yang and Jiuling Wang and Yun Chen and Zeyu Sun and Run Ming Wang and Yutian Dai},
  journal={Journal of andrology},
  year={2008},
  volume={29 5},
  pages={586-91}
}
Erectile dysfunction (ED) is a common complication of diabetes mellitus. Phosphodiesterase-5 (PDE5) inhibitors, which inhibit the breakdown of intracellular cyclic guanosine monophosphate (cGMP), are used to treat diabetic ED. Caffeine, a nonselective PDE inhibitor used in our daily diet, is controversial regarding its effect on erectile function. To investigate the effect of caffeine on erectile function in diabetic rat models and explore the mechanism, male Sprague-Dawley rats were injected… CONTINUE READING
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Endothelial dysfunction in diabetic erectile dysfunction

International Journal of Impotence Research • 2007
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