Effect of caffeine and nicotine on avoidance learning in mice: lack of interaction.

@article{Sansone1994EffectOC,
  title={Effect of caffeine and nicotine on avoidance learning in mice: lack of interaction.},
  author={Mario Sansone and Mario Battaglia and Claudio Castellano},
  journal={The Journal of pharmacy and pharmacology},
  year={1994},
  volume={46 9},
  pages={765-7}
}
Tested alone, nicotine (0.25 or 0.5 mg kg-1) improved shuttle-box avoidance learning in mice of the CD-1 strain. Caffeine had no effect at doses of 2.5 and 5 mg kg-1 and impaired performance at a dose of 10 mg kg-1. Combinations of the two drugs did not increase avoidance responses more than nicotine alone, nor was nicotine able to attenuate performance depression induced by the highest dose of caffeine. Lack of drug interaction in the avoidance test contrasts with the occurrence of interactive… CONTINUE READING