Effect of cadmium on Na-Pi cotransport kinetics in rabbit renal brush-border membrane vesicles.


Chronic exposure to cadmium impairs various renal functions, including phosphate (Pi) transport. To further investigate the mechanism of cadmium-induced alterations in renal Pi transport, kinetics of Na+-dependent Pi uptake were studied in renal cortical brush-border membrane vesicles (BBMV) exposed to CdCl2 in vitro. BBMVs isolated from rabbit renal outer… (More)


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