Effect of bronchodilation on expiratory flow limitation and resting lung mechanics in COPD.

@article{Dellac2009EffectOB,
  title={Effect of bronchodilation on expiratory flow limitation and resting lung mechanics in COPD.},
  author={Raffaele L. Dellac{\`a} and Pasquale P. Pompilio and Paul P Walker and Nicholas C Duffy and Antonio Pedotti and Peter Mark Anthony Calverley},
  journal={The European respiratory journal},
  year={2009},
  volume={33 6},
  pages={
          1329-37
        }
}
Bronchodilator drugs produce variable improvements in forced expiratory volume in 1 s (FEV(1)), but larger changes in end-expiratory lung volume (EELV) in chronic obstructive pulmonary disease (COPD), which were suggested to be related to the presence of expiratory flow limitation (EFL) at rest. We tested this concept in 42 COPD patients (FEV(1) 42.3+/-13.8% predicted) during spontaneous breathing before and after 5 mg nebulised salbutamol. EFL was detected by within-breath changes in… CONTINUE READING

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