Effect of bromantane, a new immunostimulating agent with psychostimulating activity, on the release and metabolism of dopamine in the striatum of freely moving rats. A microdialysis study

@article{Grekhova2006EffectOB,
  title={Effect of bromantane, a new immunostimulating agent with psychostimulating activity, on the release and metabolism of dopamine in the striatum of freely moving rats. A microdialysis study},
  author={Tatyana V. Grekhova and Raul R. Gainetdinov and Tatyana D. Sotnikova and L. M. Krasnykh and V. S. Kudrin and Svetlana Alexandrovna Sergeeva and I. S. Morozov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={119},
  pages={294-296}
}
It is demonstrated that bromantane induces a pronounced and prolonged (8 h) increase in the release of dopanime. Tetrodotoxin (10−6 M) perfused via a microdialysis probe partially inhibits the bromantane-induced release of dopamine. The extracellular content of the dopamine metabolites 3,4-dioxyphenylacetic and homovanillic acids is slightly decreased. The possible mechanisms of action of bromantane on the dopamin- and serotoninergic systems of the brain are discussed. 
Analysis of bromantane pharmacological spectrum
TLDR
It is concluded that psychostimulatory and anxiolytic effects are present in the spectrum of the pharmacological activity of bromantane.
Effects of the Novel Anti-Asthenic Drug Ladasten on Behavior and T-Cell Subsets Alterations in a Social Defeat Animal Model of Depression
TLDR
The notion that depression is accompanied by cell-mediated immune activation and that targeting this pathway may be a new therapeutic approach for treatment is supported and further investigations of ladasten as a potent anti-depressive drug which can be used alone as well as in combination with other anti-Depressants are supported.
cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative
TLDR
The analysis of hybridization on macroarrays has demonstrated that Ladasten alters the expression of 12 genes in the rat brain, and the changes in their activity explain the mechanisms of the anxiolytic and mood-stabilizing effects of the drug.
History of doping and doping control.
TLDR
The expression “dope” was introduced into English Turf Sport about 1900 for illegal drugging of racehorses and was extended in a broader sense to other beverages with stimulating properties.

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