Effect of bromantane, a new immunostimulating agent with psychostimulating activity, on the release and metabolism of dopamine in the striatum of freely moving rats. A microdialysis study

  title={Effect of bromantane, a new immunostimulating agent with psychostimulating activity, on the release and metabolism of dopamine in the striatum of freely moving rats. A microdialysis study},
  author={Tatyana V. Grekhova and Raul R. Gainetdinov and Tatyana D. Sotnikova and L. M. Krasnykh and V. S. Kudrin and Svetlana Alexandrovna Sergeeva and I. S. Morozov},
  journal={Bulletin of Experimental Biology and Medicine},
It is demonstrated that bromantane induces a pronounced and prolonged (8 h) increase in the release of dopanime. Tetrodotoxin (10−6 M) perfused via a microdialysis probe partially inhibits the bromantane-induced release of dopamine. The extracellular content of the dopamine metabolites 3,4-dioxyphenylacetic and homovanillic acids is slightly decreased. The possible mechanisms of action of bromantane on the dopamin- and serotoninergic systems of the brain are discussed. 
Analysis of bromantane pharmacological spectrum
It is concluded that psychostimulatory and anxiolytic effects are present in the spectrum of the pharmacological activity of bromantane.
Effects of the Novel Anti-Asthenic Drug Ladasten on Behavior and T-Cell Subsets Alterations in a Social Defeat Animal Model of Depression
The notion that depression is accompanied by cell-mediated immune activation and that targeting this pathway may be a new therapeutic approach for treatment is supported and further investigations of ladasten as a potent anti-depressive drug which can be used alone as well as in combination with other anti-Depressants are supported.
cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative
The analysis of hybridization on macroarrays has demonstrated that Ladasten alters the expression of 12 genes in the rat brain, and the changes in their activity explain the mechanisms of the anxiolytic and mood-stabilizing effects of the drug.
History of doping and doping control.
The expression “dope” was introduced into English Turf Sport about 1900 for illegal drugging of racehorses and was extended in a broader sense to other beverages with stimulating properties.


The use of tetrodotoxin for the characterization of drug-enhanced dopamine release in conscious rats studied by brain dialysis
The infusion of TTX revealed three different types of pharmacologically enhanced dopamine release in conscious rats, including action potential dependent dopamine release (exocytosis), which was observed in untreated animals as well as in animals treated with haloperidol, hal operidol + GBR 12909, and morphine.
Evidence for presynaptic antagonism by amantadine of indirectly acting central stimulants
The present data do not support the currently held view that the antiparkinsonism effect of amantadine results from its ability to potentiate the central effects of dopamine, and could be of value as a pharmacological tool in understanding the mode of action of central stimulants, and in the management of stimulant abuse.
Trans-striatal dialysis coupled to reverse phase high performance liquid chromatography with electrochemical detection: a new method for the study of the in vivo release of endogenous dopamine and metabolites
  • A. Imperato, G. Di Chiara
  • Biology, Chemistry
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1984
The biochemical and histological results obtained indicate that the method is suitable to estimate in the rat the changes in the release of endogenous DA and its metabolites which take place in vivo under administration of centrally acting drug.
Drugs affecting movement disorders.
The term "movement disorders" is under­ stand as referring to modifications in motor behav­ ior involving disturbances within the so-called "Extrapyramidal System", which is not yet clearly defined and could conceivably include disorders affecting all regions not strictly "pyramidal," such as the cerebellum and parts of the spinal cord.
ll'yuchenok, Monoaminergic Systems in the Regulation of Immune Reactions (Serotonin, Dopamine) [in Russian
  • Novosibirsk
  • 1983
Kimenis, in: Experimental and Clinical Pharmacotherapy
  • [in Russian],
  • 1986