Effect of broad-spectrum parenteral antibiotics on "colonization resistance" of intestinal microflora of humans.

Abstract

Studies with animals have shown that the normal intestinal microflora protects against colonization by new strains ("colonization resistance") and that this protective effect may be related to the anaerobic component of the microflora. However, colonization resistance has not been shown in humans. We administered cefoxitin, piperacillin, cefoperazone, and… (More)

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