Corpus ID: 6340572

Effect of brimonidine on rabbit trabecular meshwork hyaluronidase activity.

@article{Benozzi2000EffectOB,
  title={Effect of brimonidine on rabbit trabecular meshwork hyaluronidase activity.},
  author={Jorge Benozzi and Carolina O. Jaliffa and F Firpo Lacoste and D W Llomovatte and Mar{\'i}a In{\'e}s Keller Sarmiento and Ruth E. Rosenstein},
  journal={Investigative ophthalmology \& visual science},
  year={2000},
  volume={41 8},
  pages={
          2268-72
        }
}
PURPOSE To study the presence of hyaluronidase activity in the rabbit trabecular meshwork and its regulation by brimonidine. METHODS A spectrophotometric assay that consists of the assessment of N-acetylhexosamine groups released from hyaluronic acid was used to examine hyaluronidase activity. Cyclic adenosine monophosphate (cAMP) levels were assessed by radioimmunoassay. RESULTS Hyaluronidase activity was detected in the rabbit trabecular meshwork. Its optimal activity was in the acid… Expand
Effect of hyaluronic acid on intraocular pressure in rats.
TLDR
The results suggest that the intracameral administration of hyaluronic acid could be a model of ocular hypertension in rats, and significant daily variations of IOP were observed in both control and hyaluonic acid-injected eyes. Expand
A new experimental model of glaucoma in rats through intracameral injections of hyaluronic acid.
TLDR
Results indicate that the chronic administration of hyaluronic acid induced a significant decrease in the electroretinographic activity and histological changes in the retina and optic nerve that seem consistent with some features of chronic open-angle glaucoma. Expand
Ocular Biocompatibility of Carbodiimide Cross-Linked Hyaluronic Acid Hydrogels for Cell Sheet Delivery Carriers
  • J. Lai, D. H. Ma, +4 authors G. Hsiue
  • Materials Science, Medicine
  • Journal of biomaterials science. Polymer edition
  • 2010
TLDR
It is concluded that the cross-linking agent type gives influence on ocular biocompatibility of cell carriers and the EDC-HA hydrogel is an ideal candidate for use as an implantable material in cell sheet delivery applications. Expand
Bovine posterior limbus: an evaluation of an alternative source for corneal endothelial and trabecular meshwork stem/progenitor cells.
TLDR
It is shown that PET cells are present in the posterior limbus of bovine eyes and that they can be successfully cultured and expanded, thereby reducing the requirement for donor tissue for corneal transplant and invasive treatments for glaucomatous patients. Expand
Genetic Association and Gene-gene interaction of HAS2, HABP1 and HYAL3 Implicate Hyaluronan Metabolic Genes in Glaucomatous Neurodegeneration
TLDR
This is the first genetic evidence, albeit from a smaller study, that the natural polymorphisms in the genes involved in hyaluronan metabolism are potentially involved in glaucomatous neurodegeneration. Expand
Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans—A Review of the Literature
TLDR
Knowing the exact characteristics of each glaucoma experimental model could help to diminish inconveniences related to the process of the translation of results into clinical application in humans. Expand
An Overview of Glaucoma: Bidirectional Translation between Humans and Pre-Clinical Animal Models
TLDR
Revealed herein is the lack of non-IOP-related modalities in the treatment of glaucoma, which supports the use of animal models in understanding the development of glAUcoma pathophysiology and treatments. Expand
Medications Used to Treat Glaucoma
TLDR
In treating the patient, the ophthalmologist needs to take into account new understandings of risk factors as well as new concepts, such as those that suggest that aging is a major risk factor for glaucoma. Expand

References

SHOWING 1-10 OF 46 REFERENCES
Hyaluronidase in Ocular Tissues *
TLDR
The spreading reaction is a biological method, measuring the decomposing effect of hyaluronidase on the mucoids of the cement substance of rabbit's skin, and the chemical method consists in measuring the increase in reducing sugar, or in liberated acetyl-glucosamine after depolymerized hyaluronic acid. Expand
Hyaluronan in the human trabecular meshwork.
TLDR
Pronounced HA staining observed in the various layers of the trabecular meshwork suggests that substantial amount of HA is present in the nonglaucomatous outflow pathway and supports potential roles for this glycosaminoglycan in the regulation of the physiological aqueous out flow resistance or in the maintenance of the outflow channels or both. Expand
Human vitreous hyaluronidase: isolation and characterization.
TLDR
Hyaluronidase may be involved in HA catabolism in the vitreous and may play a role in determining its gel structure. Expand
Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors.
TLDR
Functional alpha 2A-ARs are present on HTM cells where they may affect the outflow pathway during the treatment of glaucoma with alpha 2-AR agonists. Expand
Exogenous hyaluronidases and degradation of hyaluronic acid in the rabbit eye.
TLDR
The results of these studies indicate that SH is more effective than TH in decreasing aqueous outflow resistance and that hyaluronic acid is an important GAG contributor to aqueously out flow resistance in the normal rabbit eye. Expand
Corneal Endothelial Hyaluronidase: A Role in Anterior Chamber Hyaluronic Acid Catabolism
TLDR
Human corneal endothelial hyaluronidase may play a role in normal anterior segment HA metabolism and in the degradation of highly concentrated HA used as a viscoelastic. Expand
Production of glycosaminoglycans by cell cultures of the trabecular meshwork of the primate eye.
TLDR
It is suggested that the gel-like properties of hyaluronic acid and the ion-binding capacity of the sulfated glycosaminoglycans might have a function in the filtering mechanism of the aqueous humor outflow. Expand
Trabecular meshwork cell culture in glaucoma research: evaluation of biological activity and structural properties of human trabecular cells in vitro.
TLDR
The presence of hyaluronidase and other lysosomal enzymes emphasizes that human trabecular cells are capable of metabolizing hyaluronic acid and other extracellular materials. Expand
Turnover of hyaluronan in the tissues
TLDR
The catabolism of hyaluronan takes place both by local degradation and drainage via the lymphatic system, and it is shown that the polysaccharide can also be endocytosed and degraded locally in the tissues. Expand
Trabecular meshwork glycosaminoglycans in human and cynomolgus monkey eye.
The glycosaminoglycans (GAGs) extractable from the trabecular meshworks (TM) of human and non-human primate eye have been analyzed by sequential enzymatic degradation and cellulose acetateExpand
...
1
2
3
4
5
...