Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver.

@article{Giantin2008EffectOB,
  title={Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver.},
  author={Mery Giantin and Monica Carletti and Francesca Capolongo and Sara Pegolo and Rosa Maria Lopparelli and Federica Gusson and C Nebbia and Michele Cantiello and Pascal G P Martin and Thierry Pineau and Mauro Dacasto},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 5},
  pages={
          885-93
        }
}
Cattle represent an important source of animal-derived food-products; nonetheless, our knowledge about the expression of drug-metabolizing enzymes (DMEs) in present and other food-producing animals still remains superficial, despite the obvious toxicological consequences. Breed represents an internal factor that modulates DME expression and catalytic activity. In the present work, the effect of breed upon relevant phase I and phase II DMEs was investigated at the pretranscriptional and post… CONTINUE READING

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