Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.

@article{Edwards2011EffectOB,
  title={Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.},
  author={Lincoln A. Edwards and Kevin Woolard and Myung Jin Son and Aiguo Li and Jeongwu Lee and Chibawanye I. Ene and Samuel A. Mantey and Dragan Maric and Hua Song and Galina I. Belova and Robert Thomas Jensen and Wei Zhang and Howard A. Fine},
  journal={Journal of the National Cancer Institute},
  year={2011},
  volume={103 15},
  pages={1162-78}
}
BACKGROUND Tumor cell invasion is the principal cause of treatment failure and death among patients with malignant gliomas. Connective tissue growth factor (CTGF) has been previously implicated in cancer metastasis and invasion in various tumors. We explored the mechanism of CTGF-mediated glioma cell infiltration and examined potential therapeutic targets. METHODS Highly infiltrative patient-derived glioma tumor-initiating or tumor stem cells (TIC/TSCs) were harvested and used to explore a… CONTINUE READING