Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects.

@article{Gainer1998EffectOB,
  title={Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects.},
  author={James V. Gainer and Jason D. Morrow and Aaron Loveland and David J. King and Nancy J. Brown},
  journal={The New England journal of medicine},
  year={1998},
  volume={339 18},
  pages={1285-92}
}
BACKGROUND Angiotensin-converting-enzyme (ACE) inhibitors not only decrease the production of angiotensin II but also decrease the degradation of bradykinin. In this study, a specific bradykinin-receptor antagonist, icatibant acetate (HOE 140), was used to determine the contribution of bradykinin to the short-term effects of ACE inhibition on blood pressure and plasma renin activity in both normotensive and hypertensive subjects. METHODS We compared the hemodynamic, renal, and endocrine… CONTINUE READING

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