Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema.

@article{Fryer2008EffectOB,
  title={Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema.},
  author={Ryan M. Fryer and John Segreti and Patricia N Banfor and Deborah L Widomski and Bradley J. Backes and Chun Wel Lin and Steve J Ballaron and Bryan F. Cox and James M Trevillyan and Glenn A. Reinhart and Thomas W. von Geldern},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 5},
  pages={947-55}
}
BACKGROUND AND PURPOSE Inhibition of bradykinin metabolizing enzymes (BMEs) can cause acute angioedema, as demonstrated in a recent clinical trial in patients administered the antihypertensive, omapatrilat. However, the relative contribution of specific BMEs to this effect is unclear and confounded by the lack of a predictive pre-clinical model of angioedema. EXPERIMENTAL APPROACH Rats were instrumented to record blood pressure and heart rate; inhibitors were infused for 35 min and bradykinin… CONTINUE READING
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