Effect of bovine lactoferrin on Chlamydia trachomatis infection and inflammation.
@article{Sessa2017EffectOB, title={Effect of bovine lactoferrin on Chlamydia trachomatis infection and inflammation.}, author={Rosa Sessa and Marisa Di Pietro and Simone Filardo and Alessia Bressan and Luigi Rosa and Antimo Cutone and Alessandra Frioni and Francesca Berlutti and Rosalba Paesano and Piera Valenti}, journal={Biochemistry and cell biology = Biochimie et biologie cellulaire}, year={2017}, volume={95 1}, pages={ 34-40 } }
Chlamydia trachomatis is an obligate, intracellular pathogen responsible for the most common sexually transmitted bacterial disease worldwide, causing acute and chronic infections. The acute infection is susceptible to antibiotics, whereas the chronic one needs prolonged therapies, thus increasing the risk of developing antibiotic resistance. Novel alternative therapies are needed. The intracellular development of C. trachomatis requires essential nutrients, including iron. Iron-chelating drugs…
37 Citations
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The present review summarizes the current evidence regarding the complex interplay between C. trachomatis and host defense factors in the genital micro-environment as well as the key findings in chronic inflammatory diseases associated to C. pneumoniae.
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Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis
- Biology, MedicineInternational journal of molecular sciences
- 2017
Human lactoferrin, an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, inhibits intracellular iron overload, an unsafe condition enhancing in vivo susceptibility to infections, as well as anemia of inflammation (AI), re-establishing IIH.
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The role of Lf against aseptic and septic inflammation has been reviewed and it is highlighted that they depend on cell models, cell metabolic status, stimulatory or infecting agents as well as on Lf iron saturation degree, integrity and purity.
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The results suggest that Ct struggles to generate a productive infection in Sertoli cells, limiting its dissemination in the host, and the adverse effect on the cytoskeleton supports the notion that Ct may compromise the blood-testis barrier, impairing spermatogenesis.
Diversity of Cervical Microbiota in Asymptomatic Chlamydia trachomatis Genital Infection: A Pilot Study
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The main finding of this study showed a marked increase in bacterial diversity in asymptomatic C. trachomatis positive women as compared to healthy controls in terms of Shannon's diversity and Shannon's evenness, suggesting that differences between the two groups depended entirely on the relative abundance of bacterial taxa rather than on the types ofacterial taxa present.
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