Effect of bortezomib on EGFR expression in head and neck squamous cell carcinoma cell lines.

@article{Wagenblast2008EffectOB,
  title={Effect of bortezomib on EGFR expression in head and neck squamous cell carcinoma cell lines.},
  author={Jens Wagenblast and Markus Hambek and Mehran Baghi and Rainald Knecht},
  journal={Anticancer research},
  year={2008},
  volume={28 2A},
  pages={
          687-92
        }
}
BACKGROUND Overexpression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma (HNSCC) has often been correlated with poor prognosis. Recent investigations have shown that the proteasome inhibitor bortezomib exhibits a high antiproliferative and apoptotic activity in HNSCC cell lines. The present study investigated whether bortezomib has an effect on EGFR expression in different squamous cell carcinoma cell lines. MATERIALS AND METHODS Six EGF-stimulated or non… CONTINUE READING

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