Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells.

@article{Xu2004EffectOB,
  title={Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells.},
  author={Wan-peng Xu and Hideki Shiba and Noriyoshi Mizuno and Yuushi Uchida and Yoshihiro Mouri and Hiroyuki Kawaguchi and Hidemi Kurihara},
  journal={Cell biology international},
  year={2004},
  volume={28 10},
  pages={675-82}
}
Bone morphogenetic proteins (BMPs) have multiple functions in the development and growth of skeletal and extraskeletal tissues. Therefore, BMPs may regulate the regeneration of periodontal tissue. To investigate this issue, we examined the effects of BMP-4, -5 and -6 on DNA synthesis and the expression of bone-related proteins in cultures of human periodontal ligament (HPL) cells. The expression of bone-related proteins was determined by Real-time polymerase chain reaction and enzyme linked… CONTINUE READING
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