Effect of bone marrow opioid peptides on antibody formation in the productive phase of the immune response

Abstract

The cells of intact spinal cord produce a group of biologically active peptides--myelopeptides (MP) stimulating antibody formation at peak of immune response and exerting an analgesic endorphin-like effect. The experiments on comparative studies of antibody-stimulating effect of synthetic opioid peptides and MP have shown that the mixture of opioid substances composed in aliquots corresponding to their content in MP has an antibody-stimulating effect similar to that of MP. Synthetic beta-endorphin also enhances the antibody formation during the productive phase of immune response at doses 1000-fold lower than its MP level. Leu- and met-enkephalins have no antibody-stimulating effect. An antagonist opiate, naloxone, blocks the antibody-stimulating activity of both opiates and MP. A close correlation between antibody-stimulating and analgetic endorphin-like MP activity has been established.

DOI: 10.1007/BF00835459

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Cite this paper

@article{Zakharova1988EffectOB, title={Effect of bone marrow opioid peptides on antibody formation in the productive phase of the immune response}, author={Ludmila A Zakharova and Raissa G Belevskaya and Augusta A Mikhailova}, journal={Bulletin of Experimental Biology and Medicine}, year={1988}, volume={105}, pages={63-66} }