Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes

@inproceedings{Gonzlez2015EffectOB,
  title={Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes},
  author={Nieves Pa{\~n}eda Gonz{\'a}lez and Antonio Mart{\'i}n-Duce and F{\'E}LIX MART{\'I}NEZ-ARRIETA and Zaida Moreno-Villegas and Sergio Portal-N{\'u}{\~n}ez and Raul Sanz and Jes{\'u}s Egido},
  booktitle={International journal of molecular medicine},
  year={2015}
}
Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein-coupled receptor (GPCR) member of the bombesin receptor family. Several studies have suggested an association between obesity, alterations in glucose metabolism, diabetes and the BRS-3 receptor. In this study, we focused on patients simultaneously diagnosed with obesity and type 2 diabetes (OB/T2D). The analysis of BRS-3 expression in the skeletal muscle of these patients revealed a marked decrease in the expression of BRS-3 at the mRNA… CONTINUE READING

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