Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure.

@article{Aaser1997EffectOB,
  title={Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure.},
  author={Ellinor Aaser and Lars Gullestad and S T\oll\ofsrud and Johan Lundberg and Christian C Hall and O. Dj\oseland and John K. Kjekshus and Kolbjorn Forfang},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={1997},
  volume={57 4},
  pages={361-7}
}
Previous studies have demonstrated that continuous infusion of furosemide results in increased diuresis and natriuresis compared with bolus administration of the drug in patients with severe heart failure. We reasoned that continuous infusion of furosemide caused less activation of neurohumoral mechanisms, since other studies have shown that bolus administration of furosemide may activate this system. We therefore tested the hypothesis that continuous administration of furosemide would increase… CONTINUE READING

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