Effect of blood flow on thrombin generation is dependent on the nature of the thrombogenic surface.

@article{Diqulou1994EffectOB,
  title={Effect of blood flow on thrombin generation is dependent on the nature of the thrombogenic surface.},
  author={Armelle Diqu{\'e}lou and Sylvie Lemozy and Dominique Dupouy and Bernard Boneu and Kjell S. Sakariassen and Yves Cadroy},
  journal={Blood},
  year={1994},
  volume={84 7},
  pages={
          2206-13
        }
}
We have investigated the influence of blood flow on thrombin generation, fibrin formation, and fibrin deposition on procoagulant and nonprocoagulant surfaces. Nonanticoagulated human blood was drawn for 5 minutes directly from an antecubital vein over stimulated endothelial cells expressing tissue factor and over human type III collagen fibrils, positioned in parallel-plate perfusion chambers. The shear rates at these surfaces were 50, 650, and 2,600 s-1. Deposition of platelets and fibrin was… CONTINUE READING

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