Effect of bixin on DNA damage and cell death induced by doxorubicin in HL60 cell line

  title={Effect of bixin on DNA damage and cell death induced by doxorubicin in HL60 cell line},
  author={Graciela Cristina dos Santos and Mara Ribeiro Almeida and Lmg Antunes and M. L. P. Bianchi},
  journal={Human \& Experimental Toxicology},
  pages={1319 - 1327}
Bixin is a natural red pigment extracted from annatto. Although it is widely used as a coloring agent in food, there are few studies about the effect of this carotenoid on DNA. This study aimed to investigate the effects of bixin on cytotoxicity and genotoxicity induced by doxorubicin in HL60 cells. At concentrations above 0.3 μg/mL, bixin demonstrated cytotoxic effects in HL60 cells. Furthermore, this carotenoid was neither mutagenic nor genotoxic to HL60 cells and reduced the DNA damage… 

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