Effect of bisphosphonates on nitric oxide production by inflammatory activated chondrocytes.

@article{Dombrecht2007EffectOB,
  title={Effect of bisphosphonates on nitric oxide production by inflammatory activated chondrocytes.},
  author={Evelyne J Dombrecht and Annemie J. M. Schuerwegh and Chris H. Bridts and Didier G Ebo and Jan F Van Offel and Wim J. Stevens and Luc S De Clerck},
  journal={Clinical and experimental rheumatology},
  year={2007},
  volume={25 6},
  pages={817-22}
}
OBJECTIVE Bisphosphonates have been reported to possess anti-inflammatory and cartilage protective effects in animal arthritis models but not much is known about their direct effect on chondrocytes. In this study we evaluate the effect of bisphosphonates on nitric oxide (NO) production by activated chondrocytes. METHODS Isolated bovine chondrocytes and bovine cartilage explants were used. In the second part of the study human cartilage explants (osteoarthritis (OA) and non-OA cartilage) were… CONTINUE READING

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