Effect of biophysical cues on reprogramming to cardiomyocytes.

@article{Sia2016EffectOB,
  title={Effect of biophysical cues on reprogramming to cardiomyocytes.},
  author={Junren Sia and Pengzhi Yu and Deepak Srivastava and Song Li},
  journal={Biomaterials},
  year={2016},
  volume={103},
  pages={
          1-11
        }
}
Reprogramming of fibroblasts to cardiomyocytes offers exciting potential in cell therapy and regenerative medicine, but has low efficiency. We hypothesize that physical cues may positively affect the reprogramming process, and studied the effects of periodic mechanical stretch, substrate stiffness and microgrooved substrate on reprogramming yield. Subjecting reprogramming fibroblasts to periodic mechanical stretch and different substrate stiffness did not improve reprogramming yield. On the… CONTINUE READING

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