Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats.

Abstract

AIM To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice. METHODS Obstructive jaundice was created in male rats by causing bile duct obstruction with polyester tape. In another group of rats, bile… (More)

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