Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

@article{Beysen2011EffectOB,
  title={Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study},
  author={Carine Beysen and Elizabeth J Murphy and Kent Deines and M. Chan and Edman Chi Tsang and Alexander Glass and Scott M. Turner and J. Protasio and Timothy J Riiff and Marc K. Hellerstein},
  journal={Diabetologia},
  year={2011},
  volume={55},
  pages={432-442}
}
The primary aim of this completed multicentre randomised, parallel, double-blind placebo-controlled study was to elucidate the mechanisms of glucose-lowering with colesevelam and secondarily to investigate its effects on lipid metabolism (hepatic de novo lipogenesis, cholesterol and bile acid synthesis). Participants with type 2 diabetes (HbA1c 6.7–10.0% [50–86 mmol/mol], fasting glucose <16.7 mmol/l, fasting triacylglycerols <3.9 mmol/l and LDL-cholesterol >1.55 mmol/l) treated with diet and… CONTINUE READING