Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.

@article{Kaur2008EffectOB,
  title={Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.},
  author={Manminder Kaur and Neil S. Holden and Sylvia M. Wilson and Maria B Sukkar and Kian Fan Chung and Peter J Barnes and Robert Newton and Mark A. Giembycz},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 3},
  pages={L505-14}
}
In diseases such as asthma, airway smooth muscle (ASM) cells play a synthetic role by secreting inflammatory mediators such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, or IL-8 and by expressing surface adhesion molecules, including ICAM-1. In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells… CONTINUE READING
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