Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.

@article{Wechsler2009EffectOB,
  title={Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.},
  author={Michael E. Wechsler and Susan J Kunselman and Vernon M. Chinchilli and Eugene Bleecker and Homer A. Boushey and William J. Calhoun and Bill T. Ameredes and Mario Castro and Timothy John Craig and Loren Clark Denlinger and John V Fahy and Nizar N Jarjour and Shamsah D Kazani and Sophia S. Kim and Monica Kraft and Stephen C. Lazarus and Robert F. Lemanske and Amy Markezich and Richard J. Martin and Perdita Permaul and Stephen P. Peters and Joe Wesley Ramsdell and Christine A. Sorkness and Everett Rand Sutherland and Stanley J Szefler and Michael J. Walter and Stephen I. Wasserman and Helene M Langevin},
  journal={Lancet},
  year={2009},
  volume={374 9703},
  pages={1754-64}
}
BACKGROUND Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly). We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid. METHODS In this multicentre… CONTINUE READING

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Arg16Gly polymorphism of the [beta]2-adrenergic receptor gene does not modulate cinical response to salmeterol in subjects with asthma

  • ER Bleecker, H Nelson, J Corren
  • J Allergy Clin Immunol
  • 2008

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