Effect of beta-propiolactone inactivation of polyoma virus on viral functions.

@article{Brown1974EffectOB,
  title={Effect of beta-propiolactone inactivation of polyoma virus on viral functions.},
  author={Arthur C. Brown and Richard A Consigli and J. Zabielski and R. Weil},
  journal={Journal of virology},
  year={1974},
  volume={14 4},
  pages={840-5}
}
Polyoma virus was inactivated by treatment with beta-propiolactone. T-antigen production, polyoma-RNA synthesis, induction of host DNA synthesis (measured by incorporation of labeled thymidine into the cell culture), and in vitro transforming ability were inactivated to a similar degree by various beta-propiolactone concentrations (0.25% beta-propiolactone reduced these functions approximately 96%), whereas plaque-forming ability and the ability of the virus to replicate its DNA and to… CONTINUE READING

From This Paper

Topics from this paper.
1 Citations
0 References
Similar Papers