Effect of beta lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study.


OBJECTIVE To examine the relation between use of antibiotics in a cohort of preschool children and nasal carriage of resistant strains of pneumococcus. DESIGN AND PARTICIPANTS Prospective cohort study over two years of 461 children aged under 4 years living in Canberra, Australia. MAIN OUTCOME MEASURES Use of drugs, respiratory symptoms, and visits to… (More)