Effect of beta-blocker therapy on survival in patients with severe aortic regurgitation results from a cohort of 756 patients.

@article{Sampat2009EffectOB,
  title={Effect of beta-blocker therapy on survival in patients with severe aortic regurgitation results from a cohort of 756 patients.},
  author={Unnati Sampat and Padmini Varadarajan and Rami J Turk and Ashvin R Kamath and Sumit Khandhar and Ramdas G Pai},
  journal={Journal of the American College of Cardiology},
  year={2009},
  volume={54 5},
  pages={452-7}
}
OBJECTIVES We sought to investigate the effect of beta-blocker (BB) therapy on survival in patients with severe aortic regurgitation (AR). BACKGROUND Beta-blockers are thought to be contraindicated in patients with AR because a slower heart rate increases the duration of diastole during which AR occurs. But AR also causes neuroendocrine activation similar to a heart failure state for which BBs are potentially beneficial. METHODS This is an observational study. Our echocardiographic database… CONTINUE READING
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