Effect of beta-adrenoceptor blockade on exercise-induced plasma catecholamine concentration-heart rate response relationship.

@article{Ohnishi1987EffectOB,
  title={Effect of beta-adrenoceptor blockade on exercise-induced plasma catecholamine concentration-heart rate response relationship.},
  author={Ai Ohnishi and Akemi Minegishi and Takashi Ishizaki},
  journal={Journal of cardiovascular pharmacology},
  year={1987},
  volume={10 6},
  pages={667-74}
}
We examined the chronotropic and sympathoadrenal responses to a strenuous exercise in eight normal subjects receiving placebo and carteolol, a nonselective beta-adrenoceptor blocker. Plasma catecholamines were measured with high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Mean plasma norepinephrine (NE) and epinephrine (E) concentrations attained at 0.5 and 2 min after exercise were significantly (p less than 0.001-0.05) greater in the carteolol trial than in… CONTINUE READING