Effect of benzyl nicotinate on the percutaneous absorption of dexamethasone in the rat

The effect of benzyl nicotinate (15 mg) on the percutaneous absorption of dexamethasone 0,1 mg (62,5 uCi)/6 cm2, in an ethanol/octanol vehicle has been investigated in the rat. Both the urinary excretion and blood concentration data showed that benzyl nicotinate had a pronounced stimulating effect on the rate and extent of absorption. The relative… (More)