Effect of benzodiazepines in 5′-nucleotidase activity of rat brain

@article{Korotkina1985EffectOB,
  title={Effect of benzodiazepines in 5′-nucleotidase activity of rat brain},
  author={R. N. Korotkina and A. A. Papin and Andrei A. Karelin},
  journal={Bulletin of Experimental Biology and Medicine},
  year={1985},
  volume={100},
  pages={1366-1368}
}
Experiments on 330 rats were made to study the influence of benzodiazepines (diazepam, dormicum and phenazepam) on 5'-nucleotidase activity in brain homogenates. It was discovered that diazepam and dormicum in doses of 3 and 4 mg, phenazepam in doses of 3.75 and 5 mg per 200 g bw provoked a 16-20% reduction in 5'-nucleotidase activity. The maximal effect of diazepam (3 and 4 mg doses) was attained 1 h after intraperitoneal injection, that of dormicum (3 mg) 30 min and of phenazepam (5 mg) 1 h… CONTINUE READING