Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.

@article{Bender1998EffectOB,
  title={Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.},
  author={Alex S. Bender and M D Norenberg},
  journal={Journal of neuroscience research},
  year={1998},
  volume={54 5},
  pages={673-80}
}
Astroglial swelling occurs in acute hyperammonemic states, including acute hepatic encephalopathy. In these conditions, the peripheral-type benzodiazepine receptor (PBR), a receptor associated with neurosteroidogenesis, is up-regulated. This study examined the potential involvement of PBRs and neurosteroids in ammonia-induced astrocyte swelling in culture. At low micromolar concentrations, the PBR antagonist PK 11195, atrial natriuretic peptide, and protoporhyrin IX, which are known to interact… CONTINUE READING