Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits.

@article{Madhu1996EffectOB,
  title={Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits.},
  author={Cherukury Madhu and Peter J. Rix and Mark J Shackleton and Thanh Thi Giang Nguyen and Diane D-S Tang-Liu},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 4},
  pages={415-8}
}
This study was designed to examine the effect of benzalkonium chloride/ethylenediaminetetraacetic acid (BAK/EDTA) on the ocular bioavailability (Focular) of ketorolac tromethamine after ocular instillation to normal and de-epithelialized corneas of rabbits both in vitro and in vivo. The in vitro Focular of the formulations was measured in flow-through perfusion chambers. For in vivo studies, a 35 microL dose of 0.5% ketorolac tromethamine with or without BAK/EDTA was instilled into rabbit eyes… CONTINUE READING

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