Effect of benazepril hydrochloride on cardiac hypertrophy in spontaneously hypertensive rats.

@article{Takemori1991EffectOB,
  title={Effect of benazepril hydrochloride on cardiac hypertrophy in spontaneously hypertensive rats.},
  author={Eiji Takemori and Yuzuru Hasegawa and Jodi Katahira and Kazutami Nakao and Toshihiko Inukai},
  journal={Arzneimittel-Forschung},
  year={1991},
  volume={41 6},
  pages={
          612-5
        }
}
To study the effects of a novel angiotensin I converting enzyme inhibitor (ACEI) on hypertension-induced cardiac hypertrophy, benazepril hydrochloride (CGS 14824 A, CAS 86541-74-4) at the dose of 3 and 10 mg/kg/d p.o. was administered to spontaneously hypertensive rats from 4 to 16 weeks of age. In addition to suppression of developing blood pressure, benazepril hydrochloride reduced both the wet weights of whole heart and left ventricle dose-dependently and significantly. Benazepril… CONTINUE READING