Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis

@article{Ryan2020EffectOB,
  title={Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis},
  author={Paul MacDaragh Ryan and Nathaniel E Hayward and Ryan Taylor Sless and Philip Garwood and Jamal Rahmani},
  journal={Obesity Reviews},
  year={2020},
  volume={21}
}
Fibroblast growth factor‐19 (FGF‐19) is a gut hormone which interacts with metabolism and is depleted in obesity. There is some indication that the hormone undergoes a resurgence following bariatric surgery (BS), an effect which may contribute to the beneficial outcomes of such procedures. This systematic review and meta‐analysis aims to synthesize the available literature on FGF‐19 levels before and after BS. MEDLINE, Scopus and Web of Science databases were searched, and the effect of… 
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Comment on “Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis”
TLDR
This review suffers from methodological issues, and subsequently, the interpretations are likely to be biased.
Neurohormonal Changes in the Gut–Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery
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The accumulate evidence suggests that the development of gut-peptide-based agents can mimic the effects of bariatric surgery and thus is a highly promising treatment strategy that could be explored in future research.
Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass
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Changes in FGF 19 and FGF 21 play differential roles in DM remission and NAFLD improvement for patients with morbidly obese and T2DM undergoing GB, while a decline in serum FGF 20 levels may reflect the improvement ofNAFLD after GB.
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Differences between MB procedures in terms of weight loss and metabolic benefit will be discussed in this review, along with the insights on clinical decision-making processes to evaluate the potential of further evolution and growth of bariatric and metabolic endoscopy.
MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake
TLDR
This review examines the recent discoveries about hormones produced in the stomach and gut, which have been reported to regulate food intake and energy expenditure in preclinical models and the association of these gut hormones to eating, energy expenditure, and weight loss after bariatric surgery in humans is discussed.
MICROBIOTA AND LIVER DISEASE: YEAR IN REVIEW
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This review will discuss the latest literature describing the role of the gut microbiota in liver diseases and suggest the liver is the first organ to encounter microbial products that cross the gut barrier and enter portal circulation.

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