Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis

@article{Ryan2020EffectOB,
  title={Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis},
  author={Paul MacDaragh Ryan and Nathaniel E Hayward and Ryan Taylor Sless and Philip Garwood and Jamal Rahmani},
  journal={Obesity Reviews},
  year={2020},
  volume={21}
}
Fibroblast growth factor‐19 (FGF‐19) is a gut hormone which interacts with metabolism and is depleted in obesity. There is some indication that the hormone undergoes a resurgence following bariatric surgery (BS), an effect which may contribute to the beneficial outcomes of such procedures. This systematic review and meta‐analysis aims to synthesize the available literature on FGF‐19 levels before and after BS. MEDLINE, Scopus and Web of Science databases were searched, and the effect of… 
Comment on “Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis”
TLDR
This review suffers from methodological issues, and subsequently, the interpretations are likely to be biased.
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This review examines the recent discoveries about hormones produced in the stomach and gut, which have been reported to regulate food intake and energy expenditure in preclinical models and the association of these gut hormones to eating, energy expenditure, and weight loss after bariatric surgery in humans is discussed.
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This review will discuss the latest literature describing the role of the gut microbiota in liver diseases and suggest the liver is the first organ to encounter microbial products that cross the gut barrier and enter portal circulation.

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