Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis

  title={Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis},
  author={Paul MacDaragh Ryan and Nathaniel E Hayward and Ryan Taylor Sless and Philip Garwood and Jamal Rahmani},
  journal={Obesity Reviews},
Fibroblast growth factor‐19 (FGF‐19) is a gut hormone which interacts with metabolism and is depleted in obesity. There is some indication that the hormone undergoes a resurgence following bariatric surgery (BS), an effect which may contribute to the beneficial outcomes of such procedures. This systematic review and meta‐analysis aims to synthesize the available literature on FGF‐19 levels before and after BS. MEDLINE, Scopus and Web of Science databases were searched, and the effect of… 
Comment on “Effect of bariatric surgery on circulating FGF‐19: A systematic review and meta‐analysis”
This review suffers from methodological issues, and subsequently, the interpretations are likely to be biased.
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The accumulate evidence suggests that the development of gut-peptide-based agents can mimic the effects of bariatric surgery and thus is a highly promising treatment strategy that could be explored in future research.
Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass
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MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake
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This review will discuss the latest literature describing the role of the gut microbiota in liver diseases and suggest the liver is the first organ to encounter microbial products that cross the gut barrier and enter portal circulation.


Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery
Results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery, and that bile salts may play a key role in the improvement of metabolism after RyGB.
Endocrine effects of duodenal-jejunal exclusion in obese patients with type 2 diabetes mellitus.
The implantation of DJBL induced a sustained reduction in body weight and improvement in regulation of lipid and glucose and the increase in FGF19 and bile acids levels could be at least partially responsible for these effects.
Bile acids synthesis decreases after laparoscopic sleeve gastrectomy.
Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials
Compared with non-surgical treatment of obesity, bariatric surgery leads to greater body weight loss and higher remission rates of type 2 diabetes and metabolic syndrome and greater improvements in quality of life and reductions in medicine use.
Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding
This study identified LAGB-induced changes in BAs and BA-induced hormones, but also revealed associations between changes in BA profile with GLP-1 and FGF19 and identified correlations with immunometabolic parameters.
Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion
RYGB-induced weight loss has unique effects on postprandial FGF21 metabolism, presumably due to rapid delivery of ingested macronutrients to the small intestine and delivery of glucose to the liver.
Mechanisms underlying weight loss after bariatric surgery
These mechanisms as well as their mediators are explored in the hope that their in-depth investigation will enable the optimization and individualization of surgical techniques, the development of equally effective but safer nonsurgical weight-loss interventions, and even the understanding of the pathophysiology of obesity itself.
Role of Bile Acids in Bariatric Surgery
It appears that bile acid alteration is an important component of bariatric surgery, and represents a promising target for the management of metabolic disorders.
Increased Bile Acids and FGF19 After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Correlate with Improvement in Type 2 Diabetes in a Randomized Trial
The association between increases in secondary, unconjugated BAs and improvements in HBA1c (but not weight) achieved after both RYGB and SG suggest manipulation of BA as a potential strategy for controlling T2DM through weight-independent means.