Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukaemia.

@article{Schie2011EffectOA,
  title={Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukaemia.},
  author={Rosalin M van Schie and Roger J M Br{\"u}ggemann and Peter M. Hoogerbrugge and Dunja Maroeska W M te Loo},
  journal={The Journal of antimicrobial chemotherapy},
  year={2011},
  volume={66 8},
  pages={1853-6}
}
BACKGROUND Vincristine is one of the cornerstones of the treatment of children with acute lymphoblastic leukaemia (ALL). Constipation, and peripheral and central neurotoxicities are the most common side effects. A comparative study exploring vincristine toxicity in individual patients receiving vincristine with and without azoles, however, is lacking. METHODS In total, 20 paediatric patients with de novo ALL were included. In each patient, vincristine toxicity in the period with and without… CONTINUE READING
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