Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial.

@article{Saiman2010EffectOA,
  title={Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial.},
  author={Lisa M Saiman and Michael I. Anstead and Nicole Mayer-Hamblett and Larry C. Lands and Margaret H Kloster and Jasna Hocevar-Trnka and Christopher H Goss and Lynn M Rose and Jane L. Burns and Bruce C. Marshall and Felix A Ratjen},
  journal={JAMA},
  year={2010},
  volume={303 17},
  pages={1707-15}
}
CONTEXT Azithromycin is recommended as therapy for cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infection, but there has not been sufficient evidence to support the benefit of azithromycin in other patients with CF. OBJECTIVE To determine if azithromycin treatment improves lung function and reduces pulmonary exacerbations in pediatric CF patients uninfected with P. aeruginosa. DESIGN, SETTING, AND PARTICIPANTS A multicenter, randomized, double-blind placebo-controlled… CONTINUE READING

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