Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP- 1 and TIMP-2) secretion by human fibroblasts in culture.

@article{KutLasserre2001EffectOA,
  title={Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP- 1 and TIMP-2) secretion by human fibroblasts in culture.},
  author={C Kut-Lasserre and C. Chaussain Miller and A. L. Ejeil and Bruno Gogly and M. F. Ben Dridi and Nathalie Piccardi and Bertrand J. Guillou and Bernard Pellat and Gaston Godeau},
  journal={Journal of periodontology},
  year={2001},
  volume={72 12},
  pages={1685-94}
}
BACKGROUND In inflamed periodontal tissues, gingival fibroblasts are able to express matrix metalloproteinases (MMPs) and their natural inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs). They can also respond to growth factors and cytokines. In this study, the in vitro effects of avocado and soybean unsaponifiable residues (ASU), their fractions (avocado unsaponifiable [ASF] or soy unsaponifiable [SSF]) on MMP-2 and MMP-3, and the activity and secretion of their inhibitors TIMP… CONTINUE READING

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