Effect of atrial natriuretic peptide on adiponectin in patients with heart failure.

Abstract

BACKGROUND The adipocyte-specific cytokine adiponectin, has cardioprotective effects, correlates with endogenous cardiac natriuretic peptides and adipocyte has guanylyl cyclase-A receptors of natriuretic peptides. AIMS To evaluate the effect of carperitide (atrial natriuretic peptide; ANP) on plasma adiponectin in patients with heart failure. METHODS AND RESULTS Seventy-five patients admitted to our hospital with decompensated heart failure were randomised (1:2) to nitroglycerin (group I: n = 23) or carperitide infusion (group II: n = 52). Blood samples were collected at baseline and after 7 days. Plasma levels of total and high-molecular weight (HMW) adiponectin, ANP and brain natriuretic peptide (BNP) were measured. There were no differences in baseline characteristics between the two groups. In group I, plasma levels of total and HMW adiponectin were significantly decreased (21.1+/-2.5 to 18.6+/-2.5 microg/mL, p<0.05, 12.3+/-1.8 to 10.8+/-1.7 microg/mL, p<0.05, respectively) concomitant with the decrease in plasma levels of ANP and BNP. In group II, plasma levels of total and HMW adiponectin were significantly increased (17.3+/-1.3 to 19.7+/-1.6 microg/mL, p<0.0001, 9.8+/-1.0 to 10.5+/-1.0 microg/mL, p<0.05, respectively) concomitant with the increase in ANP. CONCLUSIONS These findings indicate that carperitide infusion increases plasma levels of total and HMW adiponectin in patients with heart failure.

DOI: 10.1016/j.ejheart.2008.02.005

Statistics

0100200200920102011201220132014201520162017
Citations per Year

193 Citations

Semantic Scholar estimates that this publication has 193 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Tanaka2008EffectOA, title={Effect of atrial natriuretic peptide on adiponectin in patients with heart failure.}, author={Toshinari Tanaka and Takayoshi Tsutamoto and Hiroshi Sakai and Keizo Nishiyama and Masanori Fujii and Takashi Yamamoto and Minoru Horie}, journal={European journal of heart failure}, year={2008}, volume={10 4}, pages={360-6} }