Effect of atorvastatin on soluble CD14, CD40 Ligand, sE- and sP-selectins and MCP-1 in patients with type 2 diabetes mellitus: relationship to cholesterol turnover.

@article{Blha2006EffectOA,
  title={Effect of atorvastatin on soluble CD14, CD40 Ligand, sE- and sP-selectins and MCP-1 in patients with type 2 diabetes mellitus: relationship to cholesterol turnover.},
  author={Vladim{\'i}r Bl{\'a}ha and Ctirad Andr{\'y}s and Alena {\vS}mahelov{\'a} and Jir{\'i} Kn{\'i}zek and Radom{\'i}r Hy{\vs}pler and Dagmar Solichov{\'a} and Milan Blaha and Zdeněk Zad{\'a}k},
  journal={Pharmacological research},
  year={2006},
  volume={54 6},
  pages={
          421-8
        }
}
Metabolic abnormalities frequently associated with type 2 diabetes, feature besides endothelial dysfunction a novel factor of low cholesterol absorption and high cholesterol synthesis. We hypothesized an association between endothelial dysfunction and disturbances in cholesterol turnover, predisposing advanced atherosclerosis in patients with type 2 diabetes. We studied 75 patients: 30 with type 2 diabetes, 30 non-diabetic subjects with a history of cardiovascular disease, and 15 healthy… CONTINUE READING
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