Effect of atorvastatin and fluvastatin on the expression of plasminogen activator inhibitor type-1 in cultured human endothelial cells.

@article{Lopez2000EffectOA,
  title={Effect of atorvastatin and fluvastatin on the expression of plasminogen activator inhibitor type-1 in cultured human endothelial cells.},
  author={Sophie Lopez and Franck Peiretti and Bernadette Bonardo and Ir{\'e}ne Juhan-Vague and Gilles Nalbone},
  journal={Atherosclerosis},
  year={2000},
  volume={152 2},
  pages={359-66}
}
Inhibitors of HMG-CoA reductase, namely statins, improve endothelial function independently of their cholesterol-lowering effects. Plasminogen activator inhibitor type-1 (PAI-1) plays a critical role in vascular pathophysiology both at the intra- and extravascular levels. We therefore investigated the effects of atorvastatin (ATOR) and fluvastatin (FLU) on PAI-1 and also tissue-type plasminogen activator (t-PA) synthesis in 20% fetal calf serum-cultured human umbilical vein endothelial cells… CONTINUE READING
35 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Effects of statins in thrombosis and aortic lesion development in a dyslipemic rabbit model

  • J Alfon, C Pueyo Palazon, T Royo, L. Badimon
  • Thromb Haemost 1999;81:822–7
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…