Effect of asimadoline, a κ opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome

@article{Delvaux2004EffectOA,
  title={Effect of asimadoline, a $\kappa$ opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome},
  author={M. Delvaux and A. Beck and J. Jacob and H. Bouzamondo and F. Weber and J. Frexinos},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2004},
  volume={20}
}
Background : Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid κ receptors on afferent nerves may modulate it and be the target for new irritable bowel syndrome treatments. 
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  • 2011
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2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Effects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans.
...
1
2
3
4
5
...