Effect of ascorbate on abnormal neutrophil, platelet and lymphocytic function in a patient with the Chediak-Higashi syndrome.

@article{Weening1981EffectOA,
  title={Effect of ascorbate on abnormal neutrophil, platelet and lymphocytic function in a patient with the Chediak-Higashi syndrome.},
  author={Ron S. Weening and E P Schoorel and David A. Roos and M L van Schaik and A. A. Voetman and Arjen Bot and A. M. Batenburg-Plenter and C M Willems and Wim P Zeijlemaker and Alberto Astaldi},
  journal={Blood},
  year={1981},
  volume={57 5},
  pages={856-65}
}
A diminished chemotactic response was observed with the neutrophils of a patient with the Chediak-Higashi syndrome, who was not in the accelerated phase of the disease. An abnormally low release of myeloperoxidase from these cells during phagocytosis was also noted; this resulted in a decreased iodination capacity and probably also caused the defect in the intracellular killing of bacteria by the neutrophils. The level of cyclic AMP in these cells was elevated, but decreased after treatment… CONTINUE READING

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Highly Influenced

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Journal of the Medical Association of Thailand = Chotmaihet thangphaet • 2006
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Chediak-Higashi syndrome: a case report.

The Malaysian journal of pathology • 2004

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