Effect of arsenic trioxide on metallothionein and its conversion to different arsenic metabolites in hen liver

@article{Falnoga2000EffectOA,
  title={Effect of arsenic trioxide on metallothionein and its conversion to different arsenic metabolites in hen liver},
  author={Ingrid Falnoga and Vekoslava Stibilj and Majda Tu{\vs}ek-Žnidari{\vc} and Zdenka {\vS}lejkovec and Darja Mazej and Radojko Ja{\'c}imovi{\'c} and Janez {\vS}{\vc}an{\vc}ar},
  journal={Biological Trace Element Research},
  year={2000},
  volume={78},
  pages={241-254}
}
The metabolism of arsenic, its affinity to metallothionein (MT), its influence on selenium levels, and its biotransformation to different metabolites in the liver tissue of laying hens exposed to arsenic trioxide (As2O3) was investigated. The experiment was performed with two groups of hens fed for 19 d with either a standard diet or with the same diet enriched in arsenic (30 µg/g). The major findings were as follows: 1. After 19 d exposure, about 65% of the total liver As was found in the… CONTINUE READING